home
***
CD-ROM
|
disk
|
FTP
|
other
***
search
/
Shareware Overload Trio 2
/
Shareware Overload Trio Volume 2 (Chestnut CD-ROM).ISO
/
dir26
/
med9407a.zip
/
M9470136.TXT
< prev
next >
Wrap
Text File
|
1994-07-02
|
4KB
|
57 lines
Document 0136
DOCN M9470136
TI Selenium deficiency in HIV infection and the acquired immunodeficiency
syndrome (AIDS).
DT 9409
AU Dworkin BM; Section of Nutrition, New York Medical College, Valhalla
10595.
SO Chem Biol Interact. 1994 Jun;91(2-3):181-6. Unique Identifier : AIDSLINE
MED/94251844
AB Selenium is required for activity of the enzyme glutathione peroxidase,
and selenium deficiency may be associated with myopathy, cardiomyopathy
and immune dysfunction including oral candidiasis, impaired phagocytic
function and decreased CD4 T-cells. We assessed selenium status in 12
patients with AIDS compared to normals and found significantly low
plasma and red blood cell levels. Plasma selenium in AIDS was 0.043 +/-
0.01 microgram/ml vs 0.095 +/- 0.016 in controls (P < 0.001). Selenium
status correlated with serum albumin (r = 0.77; P < 0.001) and 60% had
documented GI malabsorption as determined by abnormal D-Xylose tests. In
a subsequent study blood selenium and glutathione peroxidase were
diminished in 12 AIDS and 8 ARC patients compared with normals (all P <
0.001). For glutathione peroxidase the mean levels were decreased by 45%
in AIDS and 27% in ARC versus controls (P < 0.001). Both plasma selenium
and glutathione peroxidase significantly correlated with total
lymphocyte counts (r = 0.65; P < 0.001; glutathione peroxidase and
lymphocyte counts). This occurred in both homosexuals and drug users
with AIDS and irrespective of the presence or absence of diarrhea or GI
malabsorption. To determine if tissue levels of selenium were also
depleted we studied cardiac selenium levels in autopsy AIDS hearts
compared to age and sex matched controls. Cardiac selenium in AIDS was
0.327 +/- 0.082 micrograms/g dry weight versus 0.534 +/- 0.184 in
controls (P < 0.01). Two cases had histologic cardiomyopathy
pathologically consistent with the cardiomyopathy described in Keshan
disease associated with low selenium blood levels. To further assess
mechanisms of nutrient and selenium deficiency in AIDS we studied
dietary intake in outpatients and inpatients with various stages of HIV
infection. Inadequate selenium intake based on a computer (Nutritionist
3) analysis of 72 h diet records was present in only 17% of clinically
stable HIV positive outpatients and 71% of inpatients with AIDS.
Conclusions: Selenium deficiency is common in HIV positive patients as
documented by low plasma and red blood cell levels of selenium,
diminished activity of glutathione peroxidase, and low cardiac selenium
levels in AIDS hearts. Patients with AIDS tend to have more severe
deficits than those with earlier stages of HIV infection. The selenium
deficit in blood does correlate with serum albumin levels and total
lymphocyte counts. Poor dietary intake and malabsorption could lead to
this condition which has important implications for both cardiac and
immune functions in HIV positive patients.
DE Acquired Immunodeficiency Syndrome/BLOOD/DRUG THERAPY/*METABOLISM
Female Glutathione Peroxidase/BLOOD Human HIV Infections/BLOOD/DRUG
THERAPY/*METABOLISM Male Myocardium/METABOLISM
Selenium/ADMINISTRATION & DOSAGE/BLOOD/*DEFICIENCY/THERAPEUTIC USE
JOURNAL ARTICLE REVIEW REVIEW, TUTORIAL
SOURCE: National Library of Medicine. NOTICE: This material may be
protected by Copyright Law (Title 17, U.S.Code).